Does Bupropion Cause Erectile Dysfunction? Understand the Antidepressant’s Effects on Male Sexual Health

Homem sentado na beira da cama com as mãos cobrindo o rosto representando se bupropiona causa disfunção erétil

Does Bupropion Cause Erectile Dysfunction? Understand the Antidepressant’s Effects on Male Sexual Health

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Does bupropion cause erectile dysfunction, or not? Although it is an antidepressant, the drug usually does not impair erectile function and, in some cases, may even boost libido depending on individual response. Learn more!

Bupropion is an antidepressant that treats depression and helps smokers quit. Because it is an antidepressant, many believe it causes erectile dysfunction (ED) — which is not the case.
In some men, the medication can even improve sexual performance compared with other antidepressants. Still, bupropion has side-effects that may impact other aspects of life, so medical guidance is essential.
If you use or will start this drug, keep reading to learn how bupropion works in the body and its impact on neurotransmitters and erectile function compared with other antidepressants.

How does bupropion act on the brain and the male body?

Bupropion blocks the reuptake of dopamine and norepinephrine, neurotransmitters that influence mood and energy. It is mainly prescribed to help people stop smoking, assisting in smoking control.
It is also used to treat depression and to prevent relapse after an initial positive response.
Unlike SSRIs, bupropion has little effect on serotonin — a neurotransmitter related to libido and erection control.
This medication is sold only on a retained prescription because misuse may lead to dependence.

Does bupropion cause erectile dysfunction?

For some men, higher dopamine levels from bupropion may raise libido. For others — especially those with other health issues or on multiple drugs — sexual side-effects can occur.

Erectile dysfunction is not a common side-effect. The leaflet mentions “sexual dysfunction” without specifying which problems might appear.

Comparing bupropion with other antidepressants

Studies suggest a lower incidence of erectile dysfunction with bupropion than with some SSRIs, though results vary by patient.

SSRIs tend to reduce libido and hinder erections, whereas bupropion may even increase libido in certain cases.

Because responses differ, monitor symptoms and discuss possible adjustments with your doctor.

Why do some antidepressants affect erectile function?

The erection mechanism is complex, involving neurological, hormonal and vascular factors plus arousal. Antidepressants act in the brain and can influence those pathways.

SSRIs elevate serotonin, which may dampen libido and erections. Bupropion focuses on dopamine, less tied to ED.

Risk depends on drug type and individual response, so stay alert and inform your physician.

Is antidepressant-induced erectile dysfunction permanent?

Most cases are reversible. Changing dose or medication often restores sexual function.

ED may also be psychogenic, linked to depression, anxiety or stress. Until symptoms improve or dosage is adjusted, ED can persist.

Do not stop medication without medical advice; abrupt withdrawal can worsen depression.

White man in a denim shirt holding an open pill bottle, letting two red-and-white capsules fall into his hand, illustrating whether bupropion causes erectile dysfunction

How to tell if ED is from medication or anxiety?

It is often hard to know whether ED stems from the drug or from anxiety — or both. A urologist or therapist can clarify the cause.

Accurate diagnosis requires physical exams and psychological assessment.

Alternatives and adjustments under medical guidance

If bupropion or another antidepressant triggers ED, your doctor may adjust dosage or switch drugs, or recommend other strategies to preserve sexual health.

Treatment may include medications such as sildenafil, tadalafil or intracavernosal injections. Therapy and lifestyle changes can also mitigate emotional impact and enhance quality of life.

When to see a urologist about sexual function

A urologist evaluates erection quality, investigates causes and recommends the best approach for mental and sexual health.

Occasional failure is normal, but frequent ED warrants a consultation. Although bupropion rarely causes ED, stay attentive to changes.

Instead of stopping on your own, consult your healthcare team.

Learn more:

Paulo Egydio, M.D.

PhD in Urology from USP, CRM 67482-SP, RQE 19514, Author of Geometric Principles (known as “Egydio Technique”), as well as other articles and scientific books in the area. Guest professor to teach classes and live surgeries at conferences in Brazil and abroad.

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