Does bupropion cause erectile dysfunction, or not? Although it is an antidepressant, the drug usually does not impair erectile function and, in some cases, may even boost libido depending on individual response. Learn more!
How does bupropion act on the brain and the male body?
Does bupropion cause erectile dysfunction?
For some men, higher dopamine levels from bupropion may raise libido. For others — especially those with other health issues or on multiple drugs — sexual side-effects can occur.
Erectile dysfunction is not a common side-effect. The leaflet mentions “sexual dysfunction” without specifying which problems might appear.
Comparing bupropion with other antidepressants
Studies suggest a lower incidence of erectile dysfunction with bupropion than with some SSRIs, though results vary by patient.
SSRIs tend to reduce libido and hinder erections, whereas bupropion may even increase libido in certain cases.
Because responses differ, monitor symptoms and discuss possible adjustments with your doctor.
Why do some antidepressants affect erectile function?
The erection mechanism is complex, involving neurological, hormonal and vascular factors plus arousal. Antidepressants act in the brain and can influence those pathways.
SSRIs elevate serotonin, which may dampen libido and erections. Bupropion focuses on dopamine, less tied to ED.
Risk depends on drug type and individual response, so stay alert and inform your physician.
Is antidepressant-induced erectile dysfunction permanent?
Most cases are reversible. Changing dose or medication often restores sexual function.
ED may also be psychogenic, linked to depression, anxiety or stress. Until symptoms improve or dosage is adjusted, ED can persist.
Do not stop medication without medical advice; abrupt withdrawal can worsen depression.
How to tell if ED is from medication or anxiety?
It is often hard to know whether ED stems from the drug or from anxiety — or both. A urologist or therapist can clarify the cause.
Accurate diagnosis requires physical exams and psychological assessment.
Alternatives and adjustments under medical guidance
If bupropion or another antidepressant triggers ED, your doctor may adjust dosage or switch drugs, or recommend other strategies to preserve sexual health.
Treatment may include medications such as sildenafil, tadalafil or intracavernosal injections. Therapy and lifestyle changes can also mitigate emotional impact and enhance quality of life.
When to see a urologist about sexual function
A urologist evaluates erection quality, investigates causes and recommends the best approach for mental and sexual health.
Occasional failure is normal, but frequent ED warrants a consultation. Although bupropion rarely causes ED, stay attentive to changes.
Instead of stopping on your own, consult your healthcare team.
Learn more:
- Male Self-Care: Why Is It Important for Health?
- Learn All About Enlarged Prostate: Causes, Diagnosis, and Recommended Treatments
- Does Stress Decrease Libido? Learn How to Identify and Treat It
- What Is Ejaculation? Answers to Your Main Questions
- Consequences of Male Sexual Abstinence and the Problems It Can Cause
- 10 Tips for Penis Care to Maintain Health and Prevent Infections and Diseases
- See What Causes Erectile Dysfunction and Available Treatments
- Prostate Surgery: What to Expect, Risks, and Recovery
- Gut Health and Sexual Function: The Connection




