Peyronie’s disease is characterized by the development of fibrotic plaques in the penis, causing abnormal curvature, pain, and difficulties during erections. Learn more.
A key health topic that many men, due to stigma, often neglect is their well-being. Among the issues that deserve attention is sexual health. That is why it is essential to evaluate any change in the body, including changes related to penile anatomy.
In some cases, penile curvature can worsen over time and create difficulties in sexual life, especially when there is no medical follow-up.This type of problem is known as Peyronie’s disease, and in this article you will learn about its causes and possible solutions.
What is Peyronie’s disease?
Peyronie’s disease is characterized by the development of rigid fibrous plaques in the corpora cavernosa of the penis. These plaques can cause an abnormal curvature of the penis during an erection, which can be painful and make intercourse difficult.
This curvature, which may resemble an L-shape, is only noticeable when the penis is erect. For this reason, it is important to stay alert and seek medical help to identify the problem.

Peyronie’s disease has two main phases. The inflammatory phase is the initial stage, characterized by the appearance of nodules and deformities. During this period, the patient may feel pain, especially during erections or penetration, although not everyone reports this symptom.
In the scar (chronic) phase, penile deformity becomes more stable because the fibrotic plaque is more rigid. At this stage, changes in the penis stop, but the curvature may make penetration even more difficult, depending on its severity.
Can Peyronie’s disease go away on its own?
Many men ask whether Peyronie’s disease has a cure. According to Dr. Paulo Egydio, in most cases penile curvature does not disappear spontaneously.
A study published in the Asian Journal of Urology indicates that spontaneous improvement occurs in about 3% to 13% of cases. Therefore, it is not recommended to wait for the problem to resolve on its own.
The lack of early diagnosis and proper follow-up may, in some cases, compromise penile function.
What causes Peyronie’s disease?
In most cases, Peyronie’s disease is caused by trauma and microtrauma from different factors, such as sexual activity or accidents.
During sex, for example, when the penis penetrates without being rigid enough, it is more likely to sustain impacts that, as they heal, can form fibrous tissue.
- Penile fractures: in accidents, trauma and fractures can injure tissues, trigger inflammation, and form scar tissue in the penis.
- Congenital penile curvature: a condition in which the penis has a natural curvature from birth. This occurs due to abnormal development of tissues.
- Diabetes: because diabetes can impair healing, injuries to penile tissue may increase the risk of developing Peyronie’s disease.
- Prostate surgery: sometimes prostate surgery may be associated with Peyronie’s disease, since surgery can interfere with normal blood flow to the penis, which can lead to scarring and fibrous plaques in some cases.
- Penile fibrosis: the formation of a plaque or nodule in the penile tissue that reduces elasticity, resulting in curvature. Fibrosis may be associated with narrowing or the perception of reduced penile length.
Some conditions may be associated with a higher risk of developing the disease, such as diabetes and obesity, as well as autoimmune diseases like lupus, vitiligo, and multiple sclerosis.
Is Peyronie’s disease hereditary?
Although it is an acquired condition, Dr. Paulo Egydio explains that there are hereditary factors in Peyronie’s disease that make some men more likely to develop it.
He also highlights that studies associate Peyronie’s disease with other fibrotic conditions, such as Dupuytren’s disease, which causes nodules in the palm, and Ledderhose disease, characterized by hard lumps on the soles of the feet.
According to these studies, men with a family history of these conditions have a higher risk of developing Peyronie’s disease.
Peyronie’s disease symptoms
Signs and symptoms of Peyronie’s disease to watch for include:
- Palpable nodules or lumps on the penis;
- Shortening, narrowing, or a “waist-like” indentation of the penis;
- Penile pain during erections;
- Marked penile curvature, especially if penetration during sex is difficult or impossible;
- Erectile dysfunction.
When not properly managed, Peyronie’s disease can affect physical and emotional health and overall quality of life.
Physically, beyond erectile dysfunction and pain during erections or intercourse, some men may experience reduced sensitivity in the glans (hypoesthesia).
Emotionally, Peyronie’s disease can lead to anxiety, depression, and low self-esteem, often resulting in difficulties in intimate relationships.
These factors, combined with reduced sexual satisfaction, directly impact overall well-being and make proper diagnosis and treatment essential.
Therefore, do not ignore symptoms!
Does Peyronie’s disease have a cure? Treatment options
Diagnosing Peyronie’s disease is essential to determine the stage of the condition and define the most appropriate treatment, which varies according to symptom severity and the degree of penile curvature.
It is important to discuss with a urologist which treatment best fits your case. In general, options include:
| Treatment | How it works | Indications | Advantages | Disadvantages | Estimated cost |
|---|---|---|---|---|---|
| Medications for Peyronie’s disease | Reduce inflammation and help stabilize curvature | Early or acute phase | Non-invasive; accessible | Limited effectiveness in advanced cases | Low to medium |
| Penile injections | Act on the plaque and may improve curvature | Cases with well-localized fibrous plaques | Targeted local approach | May cause local discomfort; requires repeated sessions | Medium |
| Penis pump | Gradually stretches tissue, which may help reduce curvature | Mild to moderate cases; early stage | Non-invasive | Requires prolonged daily use for meaningful results | Low to medium |
| Surgery | Removes or adjusts the fibrous plaque; may include penile prosthesis | Severe cases or significant deformity | May offer good outcomes in selected cases | Invasive; longer recovery; surgical risks | High |
| Penile prosthesis implant | Corrects deformity and addresses associated erectile dysfunction | Cases with severe associated erectile dysfunction | May treat deformity and erectile dysfunction in specific cases | Invasive; high cost | High |
It is important to emphasize the value of early diagnosis for more appropriate treatment and lower therapeutic complexity. For this reason, regular consultations with a urologist are essential.
Can Peyronie’s disease be prevented?
Some measures can help reduce risk or minimize severity. This includes:
- avoiding significant penile injuries;
- practicing safer sex to reduce sexually transmitted infections that may cause inflammation;
- maintaining a balanced diet;
- exercising regularly, including healthy habits, physiotherapy and/or individualized medical guidance;
- managing chronic medical conditions;
- avoiding smoking;
- getting regular medical checkups.
Although Peyronie’s disease does not have a definitive cure, it is possible to treat the condition to improve physical, sexual, and emotional health.
Now that you know the causes, symptoms, diagnosis, treatments, and preventive measures, set shame aside and seek help from someone who understands. Dr. Paulo Egydio, a urology specialist with extensive experience, can guide appropriate diagnosis and treatment.
Scheduling a medical evaluation can be the first step toward taking care of your sexual health and well-being. Be sure to complete your free pre-assessment on our website.


