The use of ozone therapy for Peyronie’s is still experimental. Some early studies suggest that this therapy may help reduce inflammation and improve tissue oxygenation, but it is essential to discuss this option with your doctor. Learn more.
Ozone therapy for Peyronie’s lacks extensive studies. However, urologists are starting to view this therapy as a possible complementary treatment for penile curvature in some cases.
This possibility may be interesting for patients, but it’s crucial to remember that, as it is not a consolidated treatment, it requires many precautions and considerations before trying.
Below, learn details about the procedure, potential benefits, and how it may influence penile curvature correction and erectile function.
What is ozone therapy?
Ozone therapy is a technique that involves the therapeutic application of a gas mixture of oxygen and ozone, with carefully adjusted concentrations, to treat various health conditions.
Ozone (O₃) is a molecule derived from oxygen and has biochemical properties that have been explored for therapeutic purposes. The molecule is antimicrobial, antioxidant, and immunomodulatory. Once in the body, it triggers reactions that improve blood circulation, promote cell regeneration, and reduce oxidative stress, which may benefit inflammatory and healing conditions.
It can be administered in various ways, such as injections, insufflation (rectal or vaginal), topical application, or even autohemotherapy (where the patient’s blood is mixed with ozone and reinfused).
Ozone therapy is considered an experimental treatment in Brazil, regardless of the health condition being treated. It should only be used as a complementary therapy, not as a replacement for proven treatments, and always under the supervision of healthcare professionals.
How can ozone therapy help Peyronie’s patients?
In the case of Peyronie’s disease, characterized by the formation of fibrosis in the penis, ozone therapy is viewed as a complementary treatment that may be useful in the initial inflammatory phase. During this phase, fibrotic tissue is still forming, and there is associated pain. Ozone therapy may help reduce inflammation and influence the progression of curvature.
Additionally, ozone helps improve tissue oxygenation, which could be beneficial in Peyronie’s cases where erectile dysfunction occurs due to poor or absent blood flow in the corpora cavernosa.
Generally, ozone therapy can also be explored post-surgery, as it aids wound healing and prevents infection proliferation.
What do the studies say?
Although ozone therapy has been used in various medical contexts and patients express optimism, the technique still lacks broad acceptance in medicine for all diseases. This is mainly due to the lack of randomized clinical trials that conclusively prove its effectiveness and safety.
Currently, there are no specific studies on ozone therapy for Peyronie’s.
A clinical study that evaluated the use of several non-invasive treatments for the disease, including physiotherapy and oral medications, found that ozone therapy may help, but it is impossible to distinguish whether the result is due to the combination of treatments or to the exclusive influence of ozone therapy in these cases.
In Brazil, ozone therapy is regulated for experimental use by the Unified Health System (SUS), recommended as an adjunct and in combination with recognized treatments.
Benefits of ozone therapy in treating Peyronie’s disease
It is not possible to state that ozone therapy for Peyronie’s offers benefits to patients, especially when used as the sole treatment for the disease.
However, some studies suggest that ozone therapy may help with:
- Reduction of pain, especially musculoskeletal
- Acceleration of healing
- Improvement in blood circulation
- Reduction of inflammation
- Prevention and fight against infections
Not all patients are eligible for this treatment. Patients with hyperthyroidism, autoimmune diseases, or heart diseases, for example, should not undergo ozone therapy.
Best treatments for Peyronie’s disease
Ozone therapy for Peyronie’s is an unproven treatment, but there are non-surgical and surgical treatments for this condition, depending on the stage and severity of the case.
Among the clinical options for the disease are medications such as Sildenafil and Tadalafil, which help with erectile dysfunction, and Vitamin E combined with Colchicine, which may stabilize the degree of penile curvature.
As for surgery, required when medications do not provide an adequate response, it addresses fibrosis, realigns, and expands the penis through geometric micro-cuts, with the placement of a penile prosthesis to restore penetrative capacity.
Complementary therapies may also be recommended by the urologist. This includes physiotherapy, a vacuum pump, and ozone therapy for Peyronie’s.
Since it is an experimental treatment, ozone therapy for Peyronie’s should be considered cautiously and always discussed with a trusted doctor, and Dr. Paulo Egydio can assist with this. Schedule a consultation to discuss the risks and benefits of potential treatments for Peyronie’s disease.




