The choice between tadalafil or sildenafil varies: the first has prolonged effects, the second works fast and briefly.
Tadalafil and sildenafil are medications used to treat erectile dysfunction. Both belong to the phosphodiesterase type 5 inhibitor class and help increase blood flow to the penis.
The goal of these medications is to aid in the management of erectile dysfunction, potentially contributing to improved erectile function and well-being, depending on each clinical case.
Tadalafil or sildenafil: what’s the difference?
Both are medications to treat erectile dysfunction. The main difference between tadalafil and sildenafil citrate is the duration of action.
How long does tadalafil last?
Tadalafil usually starts working about 30 minutes after intake. Its effects can last up to 36 hours.
How long does sildenafil last?
Sildenafil typically starts working 30 to 60 minutes after intake. Its effects may last 4 to 6 hours, making it a good option for those who prefer a more predictable, shorter duration.
This shorter window may be advantageous for men who prefer on-demand use, without the concern of prolonged effects interfering with other plans.
Tadalafil or sildenafil: which is better?
Tadalafil or sildenafil, which is better? It’s a common question because both are medications for erectile dysfunction.
The best option depends on each man’s needs.
For men prioritizing flexibility and spontaneity, tadalafil may be considered more suitable due to its up-to-36-hour effect, but this depends on medical evaluation.
Sildenafil may be more suitable for those who can plan intercourse, as it generally starts working 30–60 minutes after intake.
Beyond lifestyle, a physician’s assessment is essential when choosing between tadalafil or sildenafil.
Related: Can a 70-year-old man take sildenafil?
Which is safer?
Both tadalafil and sildenafil are generally considered safe when used as prescribed by a physician. However, safety varies according to each person’s health profile.
Men with pre-existing conditions (e.g., heart, kidney or liver disease) should consult a doctor before starting either medication.
Which is safer?
Both medications are considered safe when used as prescribed. Still, safety depends on individual health status.
Men with heart, kidney or liver conditions should seek medical advice before use.
Best tadalafil dose: 5 mg or 20 mg?
Many ask which tadalafil is better, 5 mg or 20 mg. It depends on goals and overall health.
Tadalafil 5 mg is often used daily; its effect is about 24 hours and can offer a predictable response to sexual stimuli.
Tadalafil 20 mg may be used on demand, with effects lasting up to 36 hours. Regardless of dose, use only under medical prescription.
Can I combine tadalafil with sildenafil?
No. Combining them may increase side effects and complications, such as a dangerous drop in blood pressure.
Follow medical guidance and use only one medication at a time, as prescribed.
Tadalafil and sildenafil side effects
More important than choosing “the best,” remember all medications can cause side effects.
Common tadalafil side effects include headache, dizziness and low blood pressure. These may be more likely if there is an undiagnosed heart condition.
And what about their relationship with cardiovascular diseases?
Men with heart disease should only use sildenafil or tadalafil after cardiology evaluation.
FAQs
Is it safe to take tadalafil or sildenafil with other medications?
It can be safe, but consult your doctor to avoid dangerous interactions.
For example, nitrates for heart disease can interact severely with PDE-5 inhibitors, leading to a sharp drop in blood pressure.
Can I drink alcohol while using tadalafil or sildenafil?
Alcohol should be consumed in moderation. It may increase side effects such as dizziness and hypotension. Excessive drinking can reduce effectiveness and raise risks.
Is occasional use harmful?
Ideally, don’t use these medications without a prescription from a urologist or cardiologist. It’s essential to investigate why erections are difficult, since erectile dysfunction has multiple causes (e.g., diabetes).
Are tadalafil or sildenafil safe for long-term use?
They may be safe with medical supervision. Ongoing use should be monitored to ensure effectiveness and detect adverse effects. Regular consultations are essential.
Do tadalafil or sildenafil delay orgasm?
Medications for erectile dysfunction may indirectly help delay orgasm.
Both tadalafil or sildenafil aim to facilitate obtaining and maintaining erections, which can boost confidence.
With improved self-confidence, some men report better control over orgasm.
Can women take tadalafil or sildenafil?
There’s no consensus. Some studies report no clear benefit for women; others suggest possible benefits.
Evidence of benefit is stronger in men, particularly for treating erectile dysfunction.
How do I know which medication is better for me?
Talk to your doctor. They’ll assess your needs, medical history, and other medications to determine the safest, most suitable option.
Choosing between tadalafil or sildenafil depends on individual factors. Both are effective for erectile dysfunction, but differ in duration and safety profile.
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Erectile dysfunction has different treatment approaches that should be discussed with a specialist according to each clinical profile.
Dr. Paulo Egydio is a urologist with experience in men’s sexual health. To determine the most appropriate treatment, an individualized medical consultation is essential.
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Learn more:
9 Main Causes of Male Impotence and How to Treat
How to improve your erection? 12 practical tips
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Erectile Dysfunction: What it is, Main Symptoms and Treatments





